US presidential hopeful Hillary Clinton has come out against the Trans-Pacific Partnership agreement championed by Barack Obama.
The landmark trade deal involves 12 countries along the Pacific rim, including the US, Australia and Japan.
In an interview Mrs Clinton said the agreement left many "unanswered questions" and did not meet the "high bar" she had set.
"I am not in favour of what I have learned about it," she told PBS.
The former Secretary of State joins rivals for the Democratic presidential nomination, Bernie Sanders and Martin O`Malley, in opposing the agreement.
The deal took five years to negotiate and covers 40% of the global economy.
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